Vitamin C, Vitamin B12, and Folic Acid for Vitiligo

There is scientific evidence that people with vitiligo are short on vitamin C, vitamin B12, and folic acid.  The relationship of vitamin C and folic acid has been reported in dermatological literature, most extensively by Montes, a world-renowned expert on the role of vitamins and nutrition in the treatment of vitiligo. Vitamin C may protect against oxidative destruction caused by reduced folates in the body. Inadequate dietary intake of vitamin C may also lead to folic acid deficiency in people who have folate levels on the low end of normal. Moreover, vitamin C is necessary for complete metabolism of tyrosine, phenylalanine, and dihydroxyphenylalanine, key components of melanin production. Some people have reported depigmenting when taking ultra-high doses of vitamin C, although it is considered unstable as an intentional depigmenting agent. When used at ultra-high dosages, vitamin C interrupts key steps in melanogenesis. It interacts with copper ions at the tyrosinase-active site and inhibits action of the enzyme tyrosinase, thereby decreasing melanin formation. Recouleur® is not formulated with an ultra-high dosage of vitamin C. Rather, it contains 60 mg of vitamin C – 100% of the Daily Value (DV). Supplementing with the recommended DV of vitamin C is particularly important for patients undergoing phototherapy because there is evidence that exposure to UV light depletes vitamin C levels. Furthermore, vitamin C has proven antioxidant properties that limit damage from long-term exposure to UVA and UVB.  UVA and UVB phototherapy are commonly used to treat vitiligo. It can be administered through a dermatologist’s office, home phototherapy, or natural sunlight. Vitamins alone or in conjunction with phototherapy (combination therapy for vitiligo) can play a part in vitiligo’s repigmentation. Recouleur® Dietary Supplement contains C, B12, and folic acid making it easier to add to your vitiligo treatment.

In future blogs, we’ll delve into the other vitamins vitiligo sufferers typically lack.  Next up: vitamin B12 followed by folic acid.

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